LED inside has reported on the nerve research of light-reactive protein in LED implants in the past three months. This is a new application of LED into medical and biotechnology, which is worthy of attention. From the University of Washington School of Medicine research, I found that mice implanted with LEDs in the laboratory, when researchers use led lights to stimulate the reward block, the blocks in their brains are inadvertently driven at the same time, which shows that Why drugs for treating depression do not seem clinically effective. It also opened up the subsequent research on the connection between led lights and brain.
Mini LED lights help researchers unveil the veil of depression and addiction
Stanford University has set a precedent for the successful use of wireless LED implants to open up new modalities using optogenetic experiments. The mouse's own energy drives the LED light to emit light, and the wireless remote control is small like a pepper seed blue LED device, which controls the nerve cells, spine or limbs of the mouse brain.
Scientists implant blue LEDs into the mouse brain for remote control
Next, researchers at Dalhousie University in Canada have made new breakthroughs, directly applying light channels to the muscles, so that even if the nerves lose their function, they can drive muscle activity.
Major breakthroughs in LED medical treatment: treatment of patients with neurological diseases such as gradual freezing
Recently, good news has been heard about medical research on implanted LED lights.
LED lights are expected to stop the pain and lead to the brain for the benefit of patients who need pain management
Scientists have developed a flexible, implantable device that can drive pain signals in the body and the spine, which means that pain can be transmitted to the brain.
Researchers at the University of Washington School of Medicine in St. Louis, East St. Louis, and the University of Illinois at Urbana-Champaign said that the implanted device could one day be used in different parts of the body to provide an alternative to pain that could not be effectively treated- Block the pain and send it to the brain.
Senior co-researcher Robert W. Gereau IV, who is also director of the University of Washington Pain Center, said: "Our ultimate goal is to use this technology to treat pain in specific areas, using a similar switch. 'The concept is blocked before the pain signal is sent to the brain."
The study was published online November 9, 2015 in Nature Biotechnology.
Some of these mice have protein cells that respond to light. Researchers hope to use LED devices to drive cells, pass on pain signals, and block the pain that general therapy can't solve, benefiting patients.
Extensible, flexible LED implants can be attached to organs such as the heart
According to Jeru, this device can be implanted into the active part of the body because it is soft and malleable. In previous studies, such devices had to be implanted and fixed to the bone.
“But when we are studying neurons on the spine or areas outside the central nervous system, we need devices that can be extended without fixing to the bone,†he said.
This new device can be fixed in one place with surgical sutures. Like the previous device, this extensible device is equipped with a miniature LED that can drive specific nerve cells. Jay said that he hopes to use this implant device to pass on the pain signal and block the pain that the general therapy can't solve, and benefit the patient.
The researchers implanted devices in genetically modified mice. Some of the nerves in these mice have protein cells that respond to light. In order to show that the implant device has an effect on the channels of pain in nerve cells, the researchers used LED lights to drive the pain of the mice. When the mouse passes through a specific area in the labyrinth, the LED light of the implant device will illuminate and drive the painful cells to make the mouse feel uncomfortable. After leaving the area of ​​the maze, the device is turned off and the pain disappears. The study found that these animals quickly learned to avoid the area to detour.
This experiment may be difficult to implement if it is an old optogenetic device, because the old device has wires that may affect the behavior of the mouse.
Research out of the laboratory plans to mass-produce LED implant devices to stimulate more relevant experiments
According to John Roger, a co-sponsor of the Department of Materials Engineering at the University of Illinois, the current micro-elastic device can be fixed with surgical sutures and may also be used in the kidneys, stomach, intestines, heart or other organs.
He added: "They offer a special, biocompatible platform that allows wireless transmission of light to virtually any organ in the body."
When Roger and Jeru designed the implant device, they paid special attention to the future mass production, so that other researchers could use this device for further research. Jeru, Roger, and Michael R. Bruchas, an associate professor of anesthesiology at the University of Washington, co-founded NeuroLux, moving toward the goal of mass production.
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